SidaGhanaV1, Main, Exploration, bibRecord, 000384

Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study

Identifieur interne : 000384 ( Main/Exploration ); précédent : 000383; suivant : 000385

Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study

Auteurs : Joseph Tuffour ; Evelyn Owusu-Mireku ; Marie-Therese Ruf ; Samuel Aboagye ; Grace Kpeli ; Victor Akuoku ; Janet Pereko ; Albert Paintsil ; Kofi Bonney ; William Ampofo ; Gerd Pluschke ; Dorothy Yeboah-Manu

Source :

The American Journal of Tropical Medicine and Hygiene [ 0002-9637 ] ; 2015.

RBID : PMC:4530737

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antibactériens (usage thérapeutique), Co-infection, Enfant, Enfant d'âge préscolaire, Femelle, Ghana (épidémiologie), Humains, Infections à VIH (), Infections à VIH (traitement médicamenteux), Infections à VIH (épidémiologie), Jeune adulte, Mycobacterium ulcerans (), Mâle, Organisation mondiale de la santé, Prise en charge de la maladie, Rifampicine (usage thérapeutique), Streptomycine (usage thérapeutique), Sujet âgé, Sujet âgé de 80 ans ou plus, Thérapie antirétrovirale hautement active, Ulcère de Buruli (), Ulcère de Buruli (traitement médicamenteux), Ulcère de Buruli (épidémiologie).
MESH :
- traitement médicamenteux : Infections à VIH, Ulcère de Buruli.
- usage thérapeutique : Antibactériens, Rifampicine, Streptomycine.
- épidémiologie : Ghana, Infections à VIH, Ulcère de Buruli.
- Adolescent, Adulte, Adulte d'âge moyen, Co-infection, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections à VIH, Jeune adulte, Mycobacterium ulcerans, Mâle, Organisation mondiale de la santé, Prise en charge de la maladie, Sujet âgé, Sujet âgé de 80 ans ou plus, Thérapie antirétrovirale hautement active, Ulcère de Buruli.
Wicri :
- geographic : Ghana.

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents (therapeutic use), Antiretroviral Therapy, Highly Active, Buruli Ulcer (complications), Buruli Ulcer (drug therapy), Buruli Ulcer (epidemiology), Child, Child, Preschool, Coinfection, Disease Management, Female, Ghana (epidemiology), HIV Infections (complications), HIV Infections (drug therapy), HIV Infections (epidemiology), Humans, Male, Middle Aged, Mycobacterium ulcerans (drug effects), Rifampin (therapeutic use), Streptomycin (therapeutic use), World Health Organization, Young Adult.
MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Rifampin, Streptomycin.
- geographic , epidemiology : Ghana.
- complications : Buruli Ulcer, HIV Infections.
- drug effects : Mycobacterium ulcerans.
- drug therapy : Buruli Ulcer, HIV Infections.
- epidemiology : Buruli Ulcer, HIV Infections.
- Adolescent, Adult, Aged, Aged, 80 and over, Antiretroviral Therapy, Highly Active, Child, Child, Preschool, Coinfection, Disease Management, Female, Humans, Male, Middle Aged, World Health Organization, Young Adult.

Abstract

The synergy between Mycobacterium tuberculosis infection and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome is well established but not so in Buruli ulcer (BU). We screened confirmed BU cases for HIV infection and followed seven BU/HIV-coinfected patients. Management of BU/HIV was based on the World Health Organization guidelines and patient condition. The HIV positivity among BU patients (8.2%; 11/134) was higher compared with that of general patients attending the facility (4.8%; 718/14,863; P = 0.07) and that of pregnant women alone (2.5%; 279/11,125; P = 0.001). All seven BU/HIV-coinfected cases enrolled in the study presented with very large (category III) lesions with four having multiple lesions compared with 54.5% of category III lesions among HIV-negative BU patients. During the recommended BU treatment with streptomycin and rifampicin (SR) all patients developed immune infiltrates including CD4 T cells in their lesions. However, one patient who received antiretroviral therapy (ART) 1 week after beginning SR treatment developed four additional lesions during antibiotic treatment, while two out of the four who did not receive ART died. Further evidence is required to ascertain the most appropriate time to commence ART in relation to SR treatment to minimize paradoxical reactions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530737

DOI: 10.4269/ajtmh.14-0571
PubMed: 26055745
PubMed Central: 4530737

Affiliations:

Le document en format XML

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<term>Buruli Ulcer (drug therapy)</term>
<term>Buruli Ulcer (epidemiology)</term>
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<term>Child, Preschool</term>
<term>Coinfection</term>
<term>Disease Management</term>
<term>Female</term>
<term>Ghana (epidemiology)</term>
<term>HIV Infections (complications)</term>
<term>HIV Infections (drug therapy)</term>
<term>HIV Infections (epidemiology)</term>
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<term>Male</term>
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<term>Mycobacterium ulcerans (drug effects)</term>
<term>Rifampin (therapeutic use)</term>
<term>Streptomycin (therapeutic use)</term>
<term>World Health Organization</term>
<term>Young Adult</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Antibactériens (usage thérapeutique)</term>
<term>Co-infection</term>
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<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
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<term>Infections à VIH ()</term>
<term>Infections à VIH (traitement médicamenteux)</term>
<term>Infections à VIH (épidémiologie)</term>
<term>Jeune adulte</term>
<term>Mycobacterium ulcerans ()</term>
<term>Mâle</term>
<term>Organisation mondiale de la santé</term>
<term>Prise en charge de la maladie</term>
<term>Rifampicine (usage thérapeutique)</term>
<term>Streptomycine (usage thérapeutique)</term>
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<term>Ulcère de Buruli (traitement médicamenteux)</term>
<term>Ulcère de Buruli (épidémiologie)</term>
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<term>Rifampin</term>
<term>Streptomycin</term>
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</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Buruli Ulcer</term>
<term>HIV Infections</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Mycobacterium ulcerans</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Buruli Ulcer</term>
<term>HIV Infections</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Buruli Ulcer</term>
<term>HIV Infections</term>
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<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
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<front><div type="abstract" xml:lang="en"><p>The synergy between <italic>Mycobacterium tuberculosis</italic>
 infection and human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome is well established but not so in Buruli ulcer (BU). We screened confirmed BU cases for HIV infection and followed seven BU/HIV-coinfected patients. Management of BU/HIV was based on the World Health Organization guidelines and patient condition. The HIV positivity among BU patients (8.2%; 11/134) was higher compared with that of general patients attending the facility (4.8%; 718/14,863; <italic>P</italic>
 = 0.07) and that of pregnant women alone (2.5%; 279/11,125; <italic>P</italic>
 = 0.001). All seven BU/HIV-coinfected cases enrolled in the study presented with very large (category III) lesions with four having multiple lesions compared with 54.5% of category III lesions among HIV-negative BU patients. During the recommended BU treatment with streptomycin and rifampicin (SR) all patients developed immune infiltrates including CD4 T cells in their lesions. However, one patient who received antiretroviral therapy (ART) 1 week after beginning SR treatment developed four additional lesions during antibiotic treatment, while two out of the four who did not receive ART died. Further evidence is required to ascertain the most appropriate time to commence ART in relation to SR treatment to minimize paradoxical reactions.</p>
</div>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Aboagye, Samuel" sort="Aboagye, Samuel" uniqKey="Aboagye S" first="Samuel" last="Aboagye">Samuel Aboagye</name>
<name sortKey="Akuoku, Victor" sort="Akuoku, Victor" uniqKey="Akuoku V" first="Victor" last="Akuoku">Victor Akuoku</name>
<name sortKey="Ampofo, William" sort="Ampofo, William" uniqKey="Ampofo W" first="William" last="Ampofo">William Ampofo</name>
<name sortKey="Bonney, Kofi" sort="Bonney, Kofi" uniqKey="Bonney K" first="Kofi" last="Bonney">Kofi Bonney</name>
<name sortKey="Kpeli, Grace" sort="Kpeli, Grace" uniqKey="Kpeli G" first="Grace" last="Kpeli">Grace Kpeli</name>
<name sortKey="Owusu Mireku, Evelyn" sort="Owusu Mireku, Evelyn" uniqKey="Owusu Mireku E" first="Evelyn" last="Owusu-Mireku">Evelyn Owusu-Mireku</name>
<name sortKey="Paintsil, Albert" sort="Paintsil, Albert" uniqKey="Paintsil A" first="Albert" last="Paintsil">Albert Paintsil</name>
<name sortKey="Pereko, Janet" sort="Pereko, Janet" uniqKey="Pereko J" first="Janet" last="Pereko">Janet Pereko</name>
<name sortKey="Pluschke, Gerd" sort="Pluschke, Gerd" uniqKey="Pluschke G" first="Gerd" last="Pluschke">Gerd Pluschke</name>
<name sortKey="Ruf, Marie Therese" sort="Ruf, Marie Therese" uniqKey="Ruf M" first="Marie-Therese" last="Ruf">Marie-Therese Ruf</name>
<name sortKey="Tuffour, Joseph" sort="Tuffour, Joseph" uniqKey="Tuffour J" first="Joseph" last="Tuffour">Joseph Tuffour</name>
<name sortKey="Yeboah Manu, Dorothy" sort="Yeboah Manu, Dorothy" uniqKey="Yeboah Manu D" first="Dorothy" last="Yeboah-Manu">Dorothy Yeboah-Manu</name>
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Le SIDA au Ghana (serveur d'exploration)

Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study

Challenges Associated with Management of Buruli Ulcer/Human Immunodeficiency Virus Coinfection in a Treatment Center in Ghana: A Case Series Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Le SIDA au Ghana (serveur d'exploration)
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